Adenosine Receptor

Receptor

P1 receptor

Adenosine Receptor

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Related Products (323)
Antibodies (2)
Adenosine Receptor Isoform Comparison

By Effects:	Inhibitors (33) Ligands (3) Agonists (102) Antagonists (152) Activators (6) Modulators (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-18776

A2AR-agonist-1	Agonist	99.90%
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.

HY-147400

Sipagladenant	Modulator	99.82%
Sipagladenant (Compound I) is an orally active adenosine receptor A2A inverse agonist. Sipagladenant can be used in frontal lobe dysfunction research.

HY-111809

N6-Ethyladenosine	Agonist	99.90%
N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with K_is of 4.9 and 4.7 nM for hA₁AR and hA₃AR, respectively.

HY-103164

(E)-8-(3-Chlorostyryl)caffeine	Antagonist	99.4%
(E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist. (E)-8-(3-Chlorostyryl)caffeine inhibits monoamine oxidase B (MAO-B) with a K_i value of 70 nM by a pathway that is independent of its actions on the A_2A receptor. (E)-8-(3-Chlorostyryl)caffeine has the potential for Parkinson's disease research.

HY-148088

M1069	Antagonist	98.04%
M1069 is a selective and orall active, dual A_2A/A_2B adenosine receptor antagonist with a selectivity of >100 fold against the A₁ and A₃ receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity.

HY-B0809R

Theophylline (Standard)	Inhibitor	99.99%
Theophylline (Standard) is the analytical standard of Theophylline. This product is intended for research and analytical applications. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-B1742

Proxyphylline	Antagonist	99.93%
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator.

HY-103180

2-Chloro-N-cyclopentyl-2′-C-methyladenosine	Agonist	99.80%
2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs).

HY-111082

ISAM-140	Inhibitor	99.85%
ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a K_i of 3.49 nM.

HY-123085

Alloxazine	Antagonist
Alloxazine is a selective A_2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC₅₀ of 2.9 μM. Alloxazine can be used for the research of cancer.

HY-106841

Draflazine		99.06%
Draflazine (R-75231) is a ENT1 inhibitor. Draflazine (R-75231) completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia and the carrageenan inflammation model of thermal and mechanical hyperalgesia.

HY-13236

LUF6000	Agonist	99.09%
LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect.

HY-106199

Adenosine A1 receptor activator T62	Activator	98.93%
Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.

HY-103162

ANR94	Antagonist
ANR94 is a potent and selective adenosine A_2A receptor (AA_2AR) antagonist with an K_i of 46 nM for hAA_2AR. ANR94 has the potential for the research of Parkinson's disease.

HY-101300

Cirazoline hydrochloride	Agonist	99.65%
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (K_i=120 nM) and only a partial agonist at α1B-AR (K_i= 960 nM) and α1D-AR (K_i=660 nM).

HY-19365

AB-MECA	Agonist	98.32%
AB-MECA is a high affinity A₃ adenosine receptor agonist with a binding K_i of 430.5 nM for human A₃ receptors in CHO cells. AB-MECA can enhance plasma histamine level.

HY-19842

GS-9667	Agonist	98.08%
GS-9667 (CVT 3619), a novel N⁶-5'-substituted adenosine analog, is a selective, partial agonist of the A₁ adenosine receptor (A₁AdoR). GS-9667 binds to adipocyte membranes with high (K_H=14 nM) and low (K_L=5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC₅₀ values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).

HY-116800

FR194921	Antagonist	98.10%
FR194921 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with K_i value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity.

HY-W011955

8-Cyclopentyl-1,3-dimethylxanthine	Antagonist	99.82%
8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with K_is of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.

HY-A0181S

Adenosine monophosphate-¹³C₁₀,¹⁵N₅ dilithium	Agonist	≥99.0%
Adenosine monophosphate-¹³C₁₀,¹⁵N₅(AMP-¹³C₁₀,¹⁵N₅) is the ¹³C-labeled and ¹⁵N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.

Inosine	A₁AR	A_2AR			99.67%
ZM241385		A2AR, Ki: 1.4 nM			99.45%
Adenosine 5'-monophosphate disodium			A2BR		99.63%
DPTN dihydrochloride				hA₃, Ki: 1.65 nM	98.66%
Derenofylline	A1R, Ki: 1 nM	A2AR, Ki: 398 nM		Adenosine A₃ receptor, Ki: 200 nM	99.93%
PSB-1115			A2BR		≥99.0%
MIPS521	A₁AR				98.21%
(E)-8-(3-Chlorostyryl)caffeine		A2AR			99.4%
M1069		A2AR	A2BR		98.04%
2-Chloro-N-cyclopentyl-2′-C-methyladenosine	A₁AR				99.80%
ISAM-140			hA_2B, Ki: 3.49 nM		99.85%
ANR94		A2AR, Ki: 46 nM (human)
AB-MECA				Adenosine A₃ receptor	98.32%
FR194921	A1R, Ki: 6.6 nM	A_2AR, Ki: 5400 nM			98.10%
Evodenoson		A2AR			99.74%
VUF-5574				Recombinant Human Adenosine A³ receptor (A³R) , Ki: 4.03 nM	99.41%
Adenosine receptor antagonist 2		A2a adenosine receptor, IC₅₀: 1 nM A2b adenosine receptor, IC₅₀: 3 nM			99.37%
PSB36	rA₁, Ki: 0.12 nM	rA_2A, Ki: 552 nM	hA_2B, Ki: 187 nM	hA₃, Ki: 2300 nM rA₃, Ki: 6500 nM	≥99.0%
Adenosine receptor inhibitor 1	A₁AR, Ki: >1000 nM	A2AR, Ki: 68.5 nM	hA_2B, Ki: >1000 nM	Adenosine A₃ receptor, Ki: >1000 nM	98.29%
MRS1334	rA₁, Ki: >100 nM	rA_2A, Ki: >100 nM		hA₃, Ki: 2.69 nM	≥99.0%
LUF5834	A1R, Ki: 2.6 nM	A2AR, Ki: 28 nM	A2BR, EC₅₀: 12 nM		99.8%
A2AAR antagonist 2		A2a adenosine receptor, IC₅₀: 33.5 nM
Adenosine receptor inhibitor 2	A₁AR, Ki: 52.2 ± 8.5 nM	A2AR, Ki: 167 ± 22 nM	hA_2B, Ki: >1000 nM	Adenosine A₃ receptor, Ki: >1000 nM
A1AR antagonist 5	hA₁AR, pKi: 6.11	hA_2AAR, pKi: <4
GW-493838	A₁AR
MRS3558		hA_2AAR, Ki: 0.6 nM rA_2A, Ki: 0.9 nM
ST 1535		A2a adenosine receptor			99.80%
A1AR antagonist 4	hA₁AR, pKi: 6.29	hA_2AAR, pKi: <4
PSB11 hydrochloride				human A3, Ki: 2.3 nM
hA3AR agonist 1				Adenosine A₃ receptor, Ki: 2.40 nM
LAS38096	A1, Ki: >1000 nM	A_2A, Ki: >2500 nM	A_2B, Ki: 17 nM	A3, Ki: >1000 nM
Adenosine receptor antagonist 5				human A3, Ki: 12 nM
LJ-4517		A2AR, Ki: 18.3 nM
A3AR antagonist 3	hA₁AR, Ki: 2.22 μM	hA_2AAR, Ki: 7.73 μM		hA₃, Ki: 37 nM
CP-608039				Adenosine A₃ receptor
SCH-202676				Adenosine A₃ receptor
A3AR agonist 4				human A3, Ki: 1.24 nM
A3AR modulator 1				Adenosine A₃ receptor
A1AR antagonist 6	hA₁AR, pKi: 7.13	hA_2AAR, pKi: <4
ATL444	rA₁, Ki: 7.0 nM	rA_2A, Ki: 2.5 nM	A2BR, Ki: 61.8 nM	rA₃, Ki: >1000 nM
A2A receptor antagonist 3	A1R, Ki: 107 nM	A2AR, Ki: 0.4 nM	A2BR, Ki: 37 nM	A3R, Ki: 1467 nM
hA2A/hCA XII modulator 1	hA₁AR, Ki: 4.819 μM	hA_2AAR, Ki: 6.4 nM		hA₃, Ki: >30 μM
A2AR-antagonist-1		A2AR, IC₅₀: 29 nM
VCP171	A1R
A2AAR/HDAC-IN-1	A₁AR, Ki: 503.3 ± 14 nM	A2AR, Ki: 163.5 ± 14 nM	hA_2B, Ki: >10000 nM	Adenosine A₃ receptor, Ki: >10000 nM
Neladenoson dalanate hydrochloride	A1R
A2A receptor antagonist 2		A2AR, IC₅₀: 8.3 nM
A3AR antagonist 1				hA₃, Ki: 4.63 nM
A3AR antagonist 2				hA₃, Ki: 4.54 nM
A2AR/A2BR antagonist 1		A2AR, IC₅₀: 11.2 nM	A2BR, IC₅₀: 6.4 nM
Neladenoson dalanate	A1R
YT 146		A2AR
MRS5698				Adenosine A₃ receptor, Ki: ~3 nM
A2A/A3 AR antagonist-1		hA_2AAR, Ki: 90 nM		hA₃, Ki: 31.8 nM
A1AR antagonist 3	human A1, Ki: 9.69 nM rat A1, Ki: 0.529 nM
A1/A3 AR antagonist 1	human A1, Ki: 36.7 nM rat A1, Ki: 1.47 nM			human A3, Ki: 25.4 nM
Adenosine receptor antagonist 1		A2AR, IC₅₀: 0.29 nM
2-Chloro-3-deazaadenosine	A1, Ki: 0.3 μM	A_2A, Ki: 0.08 μM	A_2B, Ki: 25.5 μM	A3, Ki: 1.9 μM
MRE 0094		A_2A, Ki: 0.49 μM	A_2B, Ki: 10 μM
Benzo[c][1,8]naphthyridin-6(5H)-one	hA₁AR, Ki: 4.6 μM	hA_2AAR, Ki: 4.8 μM
CVT-2759 analog	A1, Ki: 167 nM
CVT-5440	A₁, Ki: >10 (Pan)	A_2A, Ki: >5 (Pan)	A_2B, Ki: 50 nM
MRS1067				Adenosine A₃ receptor
CGH2466 dihydrochloride	A₁, IC₅₀: 19 nM		A_2B, IC₅₀: 21 nM	A3, IC₅₀: 80 nM
Adenosine receptor agonist 1				hA₃, Ki: 6.7 nM
VUF8504	human A1, Ki: 14 nM			human A3, Ki: 0.017 nM
GW 328267		A2a adenosine receptor
FLAC6		A_2AR
2-Hexynyl-5′-N-ethylcarboxamidoadenosine		A2AR

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Adenosine Receptor

Adenosine Receptor

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Related Products (323)

Antibodies (2)

Adenosine Receptor Isoform Comparison

Adenosine Receptor Related Products (323):